Tracking antimicrobial resistance transmission in urban and rural communities in Bangladesh: a One Health study of genomic diversity of ESBL-producing and carbapenem-resistant Escherichia coli .
Brandon M FlatgardAlexander D WilliamsMohammed Badrul AminJon L HobmanDov J StekelEmily K RoushamMohammad Aminul IslamPublished in: Microbiology spectrum (2024)
Our study underscores that wastewater discharged from households and wet markets carries antibiotic-resistant organisms from both human and animal sources. Thus, direct disposal of wastewater into the environment not only threatens human health but also endangers food safety by facilitating the spread of antimicrobial resistance (AMR) to surface water, crops, vegetables, and subsequently to food-producing animals. In regions with intensive poultry production heavily reliant on the prophylactic use of antibiotics, compounded by inadequate waste management systems, such as Bangladesh, the ramifications are particularly pronounced. Wastewater serves as a pivotal juncture for the dissemination of antibiotic-resistant organisms and functions as a pathway through which strains of human and animal origin can infiltrate the environment and potentially colonize new hosts. Further research is needed to thoroughly characterize wastewater isolates/populations and understand their potential impact on interconnected environments, communities, and wildlife.
Keyphrases
- antimicrobial resistance
- human health
- escherichia coli
- risk assessment
- endothelial cells
- wastewater treatment
- climate change
- anaerobic digestion
- healthcare
- public health
- gene expression
- dna methylation
- municipal solid waste
- gram negative
- multidrug resistant
- drinking water
- cystic fibrosis
- candida albicans
- social media