Monocyte distribution width alterations and cytokine storm are modulated by circulating histones.

Daniela LigiBruna Lo SassoChiara Della FrancaRosaria Vincenza GiglioLuisa AgnelloMarcello CiaccioFerdinando Mannello

Published in: Clinical chemistry and laboratory medicine (2023)

Circulating histones critically induce functional alterations of monocytes mirrored by MDW, monocyte anisocytosis, and hyperinflammation/cytokine storm in sepsis and COVID-19. MDW and circulating histones may be useful tools to predict higher risks of worst outcomes.

Keyphrases

dendritic cells
peripheral blood
sars cov
coronavirus disease
intensive care unit
acute kidney injury
immune response
metabolic syndrome
adipose tissue