Monocyte distribution width alterations and cytokine storm are modulated by circulating histones.
Daniela LigiBruna Lo SassoChiara Della FrancaRosaria Vincenza GiglioLuisa AgnelloMarcello CiaccioFerdinando MannelloPublished in: Clinical chemistry and laboratory medicine (2023)
Circulating histones critically induce functional alterations of monocytes mirrored by MDW, monocyte anisocytosis, and hyperinflammation/cytokine storm in sepsis and COVID-19. MDW and circulating histones may be useful tools to predict higher risks of worst outcomes.