Tyrosinase-activated Nanocomposites for Double-modals Imaging Guided Photodynamic and Photothermal Synergistic Therapy.

Tyrosinase (TYR) is an important biomarker of melanoma. The exploration of fluorescent pr-obes-based composites is beneficial to build an integrative platform for the diagnosis and trea-tment of melanoma. Herein, we developed a multifunctional nanocomposite IOBOH@BSA activated by TYR for selectively imaging and ablation of melanoma. The chemical structure of IOBOH enables the fluorescence (FL) imaging activated by TYR, photoacoustic (PA) ima-ging, and photodynamic-photothermal activity by regulating the balance between radiative de-cay and non-radiative decay. IOBOH combined with bovine serum albumin (IOBOH@BSA) presents the response to TYR and realizes FL imaging with mitochondria-targeting in melan-oma. Moreover, IOBOH@BSA shows excellent photothermal ability and is applied for PA imaging. After IOBOH@BSA is activated by TYR, the singlet oxygen generation increases obviously. IOBOH@BSA can realize TYR-activated imaging and photodynamic-photother-mal therapy of melanoma. The development of TYR-activated multifunctional nanocomposit-es promotes the precise imaging and improves the therapeutic effect of melanoma. This article is protected by copyright. All rights reserved.