Deletion of Mixed Lineage Kinase Domain Like Pseudokinase Aggravates Chronic Alcohol-Induced Liver Injury via Increasing Apoptosis.

Keon Hwi ImWaqar Khalid SaeedEun Bin KimA Hyeon LeeJi Eun KimSeung Min LeeXuanyuan HanningHyun Sung KimDae Won JunEileen L Yoon

Published in: Digestive diseases and sciences (2024)

MLKL deletion did not prevent chronic alcohol-induced liver damage independently of necroptosis and exacerbated hepatic steatosis by increasing hepatocyte apoptosis.

Keyphrases

oxidative stress
endoplasmic reticulum stress
cell cycle arrest
drug induced
diabetic rats
liver injury
cell death
alcohol consumption
single cell
tyrosine kinase
signaling pathway
cell proliferation