Deposition of inhaled nanoparticles is reduced in subjects with COPD and correlates with the extent of emphysema: proof of concept for a novel diagnostic technique.
H Laura AaltonenJ K JakobssonS DiazS ZackrissonE PiitulainenJ LöndahlP WollmerPublished in: Clinical physiology and functional imaging (2018)
Higher recovery for emphysema patients, relative to controls, is explained by larger diffusion distances in enlarged distal airspaces. The nanoparticle inhalation method shows potential to be developed towards a tool to diagnose emphysema.
Keyphrases
- chronic obstructive pulmonary disease
- lung function
- end stage renal disease
- pulmonary fibrosis
- newly diagnosed
- ejection fraction
- cystic fibrosis
- idiopathic pulmonary fibrosis
- chronic kidney disease
- peritoneal dialysis
- minimally invasive
- climate change
- patient reported outcomes
- risk assessment
- human health
- patient reported