Biomarkers of oxidative stress and its nexus with haemoglobin variants and adverse foeto-maternal outcome among women with preeclampsia in a Ghanaian population: A multi-centre prospective study.
Ganiwu AbdulWilliam Osei-WusuGordon Akuffo AsareSamira DaudStephen OpokuValentine Christian Kodzo Tsatsu TamakloeJoseph FrimpongBenedict SackeyWina Ivy Ofori BoaduVivian PaintsilMax Efui Annani-AkollorYaw Amo WiafeEnoch Odame AntoOtchere Addai-MensahPublished in: PloS one (2023)
Reduced levels of vitamin C are common among preeclamptics with at least one copy of the HbC variant. Haemoglobin variants in preeclampsia contribute to adverse foeto-maternal outcomes with Haemoglobin S variants being the most influencing factor for PPH, HELLP, preterm labour, NICU admission, and neonatal jaundice.
Keyphrases
- pregnancy outcomes
- copy number
- oxidative stress
- early onset
- birth weight
- gestational age
- preterm infants
- emergency department
- pregnant women
- low birth weight
- dna methylation
- body mass index
- physical activity
- ischemia reperfusion injury
- endoplasmic reticulum stress
- metabolic syndrome
- electronic health record
- heat shock