On the effect heterogeneity of established disease susceptibility loci for Alzheimer's disease across different genetic ancestries.

Sanghun LeeJulian HeckerGeorg HahnKristina Mullinnull nullSharon M LutzRudolph E TanziChristoph LangeDmitry Prokopenko

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

We observed substantial heterogeneity for the APOE-harboring 19q13.32 region with TOMM40/APOE/APOC1 genes. The largest risk effect was seen among African Americans, while Asians showed a surprisingly small risk effect.

Keyphrases

cognitive decline
genome wide
high fat diet
metabolic syndrome
adipose tissue
transcription factor
mild cognitive impairment
insulin resistance
skeletal muscle
genome wide identification
genome wide association