Brain Atrophy and Physical and Cognitive Disability in Multiple Sclerosis.
Luis Ignacio Casanova PeñoCarlos López De Silanes De MiguelLaura de TorresMiriam Eimil OrtizMaría José Gil MorenoBeatriz Oyanguren RodeñoRodrigo Terrero CarpioJulia Sabín MuñozBlanca Patricia Díaz MontoyaMiguel Ángel Saiz SepúlvedaEsther De Antonio SanzSara Abellán AyusoMarta González SalaicesPublished in: Basic and clinical neuroscience (2023)
Conventional magnetic resonance imaging (MRI) is still used for diagnosing and monitoring multiple sclerosis (MS). Analysis of Brain volumes including Whole brain volume (WBV), gray matter volume (GMV), and T2 lesion load (T2L) allows the evaluation of its neurodegenerative mechanisms. Robust evidence links brain atrophy with disability in MS. This study aims to analyze the relationship between advanced MRI sequences and physical disability and cognitive functioning in MS patients. According to the results, T2L was associated with physical disability and GMV was associated with age and physical disability. There was no significant correlation between cognitive impairment and cerebral volumes in patients with MS.
Keyphrases
- multiple sclerosis
- white matter
- magnetic resonance imaging
- physical activity
- resting state
- mental health
- contrast enhanced
- cognitive impairment
- end stage renal disease
- functional connectivity
- mass spectrometry
- chronic kidney disease
- computed tomography
- ejection fraction
- prognostic factors
- ms ms
- peritoneal dialysis
- diffusion weighted imaging
- patient reported outcomes