Characterization of myelodysplastic syndromes hematopoietic stem and progenitor cells using mass cytometry.

Costa BachasCarolien DuetzMargot F van SpronsenJan VerhoeffJuan J Garcia VallejoJoop H JansenJacqueline CloosTheresia M WestersArjan A van de Loosdrecht

Published in: Cytometry. Part B, Clinical cytometry (2022)

High-dimensional mass cytometry and computational data analyses enabled characterization of HSPC subsets in MDS and identification of leukemia stem cell populations based on their immunophenotype. Stem cells in MDS that display leukemia-associated features may predict the risk of developing AML.

Keyphrases

stem cells
acute myeloid leukemia
single cell
bone marrow
cell therapy
electronic health record
allogeneic hematopoietic stem cell transplantation
big data
peripheral blood
mesenchymal stem cells
artificial intelligence
machine learning
deep learning
genetic diversity