Simultaneous two-photon activation and imaging of neural activity based on spectral-temporal modulation of supercontinuum light.
Yuan-Zhi LiuCarlos A RenteriaConnor D CourtneyBaher IbrahimSixian YouEric J ChaneyRonit BarkalifaRishyashring R IyerMantas ZurauskasHaohua TuDaniel A LlanoCatherine A Christian-HinmanStephen A BoppartPublished in: Neurophotonics (2020)
A PCF-based supercontinuum light source was employed for simultaneous imaging and excitation of calcium dynamics in brain tissue. Pumped PCFs can serve as powerful light sources for imaging and activation of neural activity, and overcome the limited spectra and space associated with multilaser approaches.