Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer.
Demetra P KelenisKathia E RodarteRahul K KolliparaKarine PozoShreoshi Pal ChoudhuriKyle B SpainhowerSarah J WaitVictor StastnyTrudy G OliverJane E JohnsonPublished in: Cancer research (2022)
The identification of KPNB1 as a nuclear import receptor for lineage-defining transcription factors in SCLC reveals a viable therapeutic strategy for cancer treatment.