Combined genome-wide linkage and targeted association analysis of head circumference in autism spectrum disorder families.
Marc R Woodbury-SmithD A BilderJ MorganL JerominskiT DarlingtonT DyerA D PatersonH CoonPublished in: Journal of neurodevelopmental disorders (2017)
Although this region does not overlap with ASD linkage signals in these same samples, it has been associated with other psychiatric risk, including ADHD, developmental dyslexia, schizophrenia, specific language impairment, and juvenile bipolar disorder. The genome-wide significant linkage signal represents the first reported observation of a potential quantitative trait locus for HC in ASD and may be relevant in the context of complex multivariate risk likely leading to ASD.
Keyphrases
- autism spectrum disorder
- genome wide
- bipolar disorder
- attention deficit hyperactivity disorder
- dna methylation
- intellectual disability
- copy number
- major depressive disorder
- body mass index
- mental health
- gene expression
- hiv testing
- high resolution
- working memory
- risk assessment
- climate change
- body weight
- men who have sex with men