Inaccurately Reported Statin Use Affects the Assessing of Lipid Profile Measures and Their Association with Coronary Artery Disease Risk.
Anna A IvanovaMichael S GardnerJennifer D KusovschiBryan A ParksDavid M SchieltzAkshay BarejaRobert W McGarrahWilliam E KrausZsuzsanna KuklenyikJames L PirkleJohn R BarrPublished in: Clinical chemistry (2024)
Our study uncovered prominent discrepancies between medication records and actual statin use measured by mass spectrometry. We showed that inaccurate statin use assessments may lead to overestimation and underestimation of LDL levels in statin user and nonuser categories, exaggerating the reverse epidemiology association between LDL levels and CAD diagnosis. Combining medication history and quantitative statin assay data can significantly improve the design, analysis, and interpretation of clinical and epidemiological studies.
Keyphrases
- coronary artery disease
- low density lipoprotein
- cardiovascular disease
- mass spectrometry
- percutaneous coronary intervention
- cardiovascular events
- coronary artery bypass grafting
- healthcare
- high resolution
- type diabetes
- risk factors
- high throughput
- machine learning
- deep learning
- capillary electrophoresis
- acute coronary syndrome
- single cell
- transcatheter aortic valve replacement