Maraviroc inhibits SARS-CoV-2 multiplication and s-protein mediated cell fusion in cell culture.
Kenneth H RisnerKatie V TieuYafei WangAllison BakovicFarhang AlemNishank BhallaSteven D NathanDaniel E ConwayPaul MacklinAarthi NarayananPublished in: bioRxiv : the preprint server for biology (2020)
Maraviroc, FTY720, Nitazoxanide and Atorvastatin inhibit SARS-CoV-2 multiplication in cell culture.Maraviroc does not interfere with the interaction between SARS-CoV-2 spike protein and ACE2 receptor.Maraviroc exhibits only modest synergistic activities with FTY720, Nitazoxanide or Atorvastatin.Maraviroc reduces the extent of SARS-CoV-2 S-protein mediated cell fusion.Mathematical modeling reveals that Maraviroc treatment will elicit an exponential decrease in viral load in a multicellular tissue environment.