A Dual Receptor Targeting- and BBB Penetrating- Peptide Functionalized Polyethyleneimine Nanocomplex for Secretory Endostatin Gene Delivery to Malignant Glioma.

Lu LuHongyuan ChenLongkun WangLin ZhaoYanna ChengAijun Wang Feng-Shan Wang Xinke Zhang

Published in: International journal of nanomedicine (2020)

Our study demonstrates that PPTA/pVAXI-En can be exploited as an efficient dual-targeting nanocomplex to cross the BBB and BTB, and hence it represents a feasible and promising nonviral gene delivery system for effective glioma therapy.

Keyphrases

blood brain barrier
cancer therapy
genome wide
copy number
quantum dots
mass spectrometry
bone marrow
dna methylation
drug delivery
mesenchymal stem cells
binding protein
transcription factor