Counteracting Angiotensinogen Small-Interfering RNA-Mediated Antihypertensive Effects With REVERSIR.

Dien Ye Edwyn O Cruz-López Richard van Veghel Ingrid M GarreldsAnne KasperKelly WassarmanHo-Chou Tu Ivan ZlatevA H Jan Danser

Published in: Hypertension (Dallas, Tex. : 1979) (2024)

In spontaneously hypertensive rats, angiotensinogen-RVR dose-dependently reversed AGT siRNA-induced AGT reduction, normalizing MAP. MAP normalization persisted even with 50% recovered AGT levels, likely due to upregulated renin maintaining adequate angiotensin generation. Post-AGT-RVR dosing, a second AGT siRNA dose lowered MAP again.

Keyphrases

high density
cancer therapy
blood pressure
oxidative stress
drug delivery
drug induced
hyaluronic acid
nucleic acid