Cytoskeletal protein SPTA1 mediating the decrease in erectile function induced by high-fat diet via Hippo signaling pathway.

Ying ChenLei WangZhan-Sen HuangJia-Xin FengShi-Xiong LiZi-Jun DuZe-Bo ZhangJing LiuJian YangZhi-Ming HuZhi-Lin WangJun Chen

Published in: Andrology (2022)

The down-regulation of SPTA1 in SD rats fed with HFD may induce cell pyroptosis and lead to the decrease of erectile function by activating the Hippo pathway; these findings may provide new therapeutic targets for improving erectile function.

Keyphrases

high fat diet
signaling pathway
insulin resistance
adipose tissue
benign prostatic hyperplasia
type diabetes
pi k akt
metabolic syndrome
bone marrow
induced apoptosis
cell proliferation
nlrp inflammasome
endoplasmic reticulum stress