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Amniotic fluid pentraxins: Potential early markers for identifying intra-amniotic inflammatory complications in preterm pre-labor rupture of membranes.

Ivana MusilovaCtirad AndrysJan KrejsekMarcela DrahosovaBarbora ZednikovaLenka PliskovaHelena ZemlickovaBo JacobssonMarian Kacerovsky
Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2017)
In this study, pentraxin 3 (PTX3), C-reactive protein (CRP), and serum amyloid P component (SAP) concentrations in the amniotic fluid of women with preterm pre-labor rupture of membranes (PPROM) were evaluated based on evidence of microbial invasion of the amniotic cavity (MIAC), intra-amniotic inflammation (IAI), and microbial-associated IAI. A total of 149 women with PPROM were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis. Amniotic fluid PTX3, SAP, and CRP concentrations were assessed using enzyme-linked immunosorbent assay. PTX3 and CRP concentrations were higher in women with MIAC, IAI, and microbial-associated IAI than in women without these conditions. SAP concentrations were only higher in the presence of IAI and microbial-associated IAI. Amniotic fluid PTX3 concentrations of 11 ng/mL were found to be the best value for identifying the presence of microbial-associated IAI and IAI in women with PPROM. To conclude, amniotic fluid pentraxins are involved in intra-amniotic inflammatory responses in pregnancies complicated by PPROM.
Keyphrases
  • umbilical cord
  • mesenchymal stem cells
  • oxidative stress
  • preterm birth
  • type diabetes
  • gestational age
  • risk factors
  • risk assessment
  • polycystic ovary syndrome
  • skeletal muscle
  • insulin resistance