Effect of burosumab on muscle function and strength, and rates of ATP synthesis in skeletal muscle in adults with XLH.

Karl L InsognaRebecca SullivanStephen Parziale Yanhong DengDiana CarranoChristine SimpsonSylvie DufourThomas CarpenterKitt Falk Petersen

Published in: The Journal of clinical endocrinology and metabolism (2023)

The improvement in the 6MW and STS tests without changes in muscle strength or ATP synthesis rates suggests that reductions in pain, fatigue and stiffness may partly explain the improved performance. Intracellular phosphate in skeletal muscle is insulated from hypophosphatemia in XLH.

Keyphrases

skeletal muscle
insulin resistance
chronic pain
pain management
neuropathic pain
sleep quality
reactive oxygen species
metabolic syndrome
spinal cord injury
adipose tissue
spinal cord