Incorporating Differential Gene Expression Analysis with Predictive Biomarkers to Identify Novel Therapeutic Drugs for Fuchs Endothelial Corneal Dystrophy.

Huaming WenRyan A GalloXiaosheng HuangJiamin CaiShaoyi MeiAmmad Ahmad FarooqiJun Zhao Wensi Tao

Published in: Journal of ophthalmology (2021)

Based on differential gene expression signatures, several candidate drugs have been identified to reverse the disease phenotypes in FECD. Gene expression signature with LINCS small molecule prediction software can discover novel preclinical drug candidates for FECD.

Keyphrases

gene expression
small molecule
dna methylation
genome wide
early onset
stem cells
drug induced
protein protein
mesenchymal stem cells
cell therapy
wound healing
bone marrow
data analysis