Pre-treatment drug resistance and HIV-1 genetic diversity in the rural and urban settings of Northwest-Cameroon.
Joseph FokamDesire TakouGeorges TetoShu E NforbihOdine P KomeMaria M SantoroEzechiel S NgoufackMbuh EyongetahDenis PalmerEstella T FokunangCharles N FokunangVittorio ColizziCarlo-Federico PernoAlexis NdjoloPublished in: PloS one (2020)
PDR is at a moderate rate in the Northwest region of Cameroon, with higher burden within urban populations. CRF02_AG is the most predominant clade in both urban and rural settings. No effect of HIV molecular epidemiology and CD4-staging on the presence of PDR in patients living in these settings was found. Our findings suggest close monitoring, NNRTI-sparing regimens or sequencing for patients initiating ART, especially in urban settings.
Keyphrases
- end stage renal disease
- antiretroviral therapy
- genetic diversity
- newly diagnosed
- hiv infected
- ejection fraction
- chronic kidney disease
- hiv positive
- human immunodeficiency virus
- hepatitis c virus
- peritoneal dialysis
- hiv aids
- hiv testing
- lymph node
- men who have sex with men
- high intensity
- quantum dots
- pet ct
- smoking cessation
- replacement therapy