VRK1 Is a Synthetic-Lethal Target in VRK2-Deficient Glioblastoma.

Julie A Shields Samuel R Meier Madhavi Bandi Erin E Mulkearns-Hubert Nicole Hajdari Maria Dam Ferdinez Justin L Engel Daniel J Silver Binzhang Shen Wenhai Zhang Christopher G Hubert Kelly Mitchell Sajina Shakya Shan-Chuan Zhao Alborz Bejnood Minjie Zhang Robert Tjin Tham Sjin Erik Wilker Justin D Lathia Jannik N Andersen Yingnan Chen Fang Li Barbara Weber Alan Huang Natasha Emmanuel

Published in: Cancer research (2022)

A paralog synthetic-lethal interaction between VRK1 and VRK2 sensitizes VRK2-methylated glioblastoma to perturbation of VRK1 kinase activity, supporting VRK1 as a drug discovery target in this disease.

Keyphrases

drug discovery
oxidative stress
induced apoptosis
protein kinase
wild type