Long-term outcomes of intensity-modulated radiation therapy combined with neoadjuvant androgen deprivation therapy under an early salvage policy for patients with T3-T4N0M0 prostate cancer.
Takashi MizowakiYoshiki NorihisaKenji TakayamaItaru IkedaHaruo InokuchiKiyonao NakamuraTomomi KambaTakahiro InoueToshiyuki KamotoOsamu OgawaMasahiro HiraokaPublished in: International journal of clinical oncology (2015)
High-dose IMRT, combined with NA-ADT for LAPC, was associated with favorable long-term disease-specific and overall survival outcomes, despite non-provision of A-ADT under the early S-ADT provision policy. This approach may represent a viable alternative to uniform provision of long-term A-ADT, because two-thirds of the patients maintained ADT-free status over an 8-year period after IMRT. Prospective trials will be required.
Keyphrases
- prostate cancer
- high dose
- radiation therapy
- public health
- healthcare
- palliative care
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- locally advanced
- low dose
- rectal cancer
- radical prostatectomy
- lymph node
- stem cells
- patient reported outcomes
- mesenchymal stem cells
- radiation induced
- patient reported
- cell therapy