Multifunctional Photothermal Hydrogel in the Second Near-Infrared Window for Localized Tumor Therapy.
Sha LuYingjiao WuYandi LiuXiaoyi SunJianghua LiJuan LiPublished in: ACS applied bio materials (2023)
A copper selenide-embedded gellan gum hydrogel (Cu 2- x Se@GG) is designed as an "all-in-one" antitumor agent. The obtained nanocomposite hydrogel exhibits strong near-infrared light absorption and high photothermal conversion efficiency in both the NIR-I and NIR-II biowindows. The photothermal conversion efficiency achieves 58.8% under the irradiation of 0.75 W/cm 2 with a 1064 nm laser. Furthermore, the nanocomposite hydrogel has catalase- and peroxidase-mimicking activities, which could alter the tumor microenvironment by reducing hypoxia and/or increasing the production of reactive oxygen species. Moreover, the multifunctional Cu 2- x Se@GG nanocomposite hydrogel can also be used as an immune agonist resiquimod (R848) carrier to promote immune regulation and enhance the therapeutic effect. The single-syringe R848/Cu 2- x Se@GG treatment achieves synergetic photothermal immunotherapy, showing 97.4% of tumor regression rate from an initial large tumor of 300 mm 3 .
Keyphrases
- drug delivery
- drug release
- cancer therapy
- photodynamic therapy
- aqueous solution
- reduced graphene oxide
- hyaluronic acid
- reactive oxygen species
- quantum dots
- wound healing
- metal organic framework
- hydrogen peroxide
- fluorescence imaging
- highly efficient
- gold nanoparticles
- endothelial cells
- radiation induced
- high speed
- visible light
- bone marrow
- solid phase extraction
- mesenchymal stem cells
- simultaneous determination
- replacement therapy