Integrative transcriptome analysis of malignant pleural mesothelioma reveals a clinically relevant immune-based classification.
Ania AlayDavid CorderoSara Hijazo-PecheroElisabet AliagasAdriana Lopez-DorigaRaúl MarínRamón PalmeroRoger LlatjósIgnacio EscobarRicard RamosSusana PadronesVíctor MorenoErnest NadalXavier SoléPublished in: Journal for immunotherapy of cancer (2021)
This study identifies a novel immune-based signature with potential clinical relevance based on TH2 and TC levels, unveiling a fraction of patients with MPM with better prognosis and who might benefit from immune-based therapies. Molecular specificities of the different groups might be used to tailor specific potential therapies in the future.