Inhibition of VEGFR2 and EGFR signaling cooperatively suppresses the proliferation of oral squamous cell carcinoma.

Maho OndaAkinobu OtaKunihiro ItoTakayuki OnoSivasundaram KarnanMikako KatoSayuri KondoAkifumi FuruhashiTomio HayashiYoshitaka HosokawaYoshiaki Kazaoka

Published in: Cancer medicine (2023)

VEGFR-mediated signaling would be an alternative signaling pathway for the survival of OSCC cells under the disruption of EGFR signaling. These results highlight the clinical application of VEGFR inhibitors in the development of multi-molecular-targeted therapeutics against OSCC.

Keyphrases

signaling pathway
induced apoptosis
small cell lung cancer
vascular endothelial growth factor
epidermal growth factor receptor
tyrosine kinase
oxidative stress
cell cycle arrest
cell proliferation