Low dose-rate irradiation with [3H]-labelled valine to selectively target hypoxic cells in a human colorectal cancer xenograft model.

Stine Gyland MikalsenLars Tore Gyland MikalsenJoe Alexander SandvikEva-Katrine AarnesSiri FenneNorman John CarrHeidi LyngNina Frederike Jeppesen EdinErik Olai Pettersen

Published in: Acta oncologica (Stockholm, Sweden) (2018)

Continuous low-dose-rate irradiation was well tolerated by aerobic tissue. This indicates a potential use of low dose-rate irradiation to target hypoxic tumor cells in combination with high dose-rate irradiation to eradicate the well oxygenated tumor regions. However, [3H]-valine is not the appropriate method to deliver ultra-low dose-rate irradiation in vivo.

Keyphrases

low dose
high dose
stem cell transplantation
endothelial cells
radiation induced
induced apoptosis
high resolution
radiation therapy
mass spectrometry
risk assessment
cell proliferation
climate change
signaling pathway
oxidative stress
high intensity
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