Tissue requirements for the application of aortic valve neocuspidization - appropriate pericardium properties and homogeneity?
Claudia DittfeldSophia BähringCindy WelzelAnett JannaschKlaus MatschkeSems-Malte TugtekinKonstantin AlexiouPublished in: Journal of materials science. Materials in medicine (2024)
Human pericardia exhibited a higher heterogeneity in collagen content, density of vessel structures and elastic moduli. Thickness, vessel density and collagen and elastin content differed significantly between the species. In contrast, significant interindividual differences were detected in most properties investigated for human pericardial samples but only for tissue thickness in bovine tissues. Higher heterogeneity of human pericardium, differing vessel and collagen content compared to bovine state-of-the-art material might be detrimental for long term AV functionality or deterioration and have to be intensely investigated in patients follow up after autologous cusp replacement.
Keyphrases
- aortic valve
- endothelial cells
- end stage renal disease
- induced pluripotent stem cells
- transcatheter aortic valve replacement
- gene expression
- single cell
- ejection fraction
- chronic kidney disease
- magnetic resonance
- stem cells
- aortic valve replacement
- aortic stenosis
- peritoneal dialysis
- high resolution
- left ventricular
- bone marrow
- mass spectrometry
- prognostic factors
- atomic force microscopy
- patient reported outcomes
- resting state
- functional connectivity
- platelet rich plasma