In Vitro and In Vivo Antileishmanial Activity of Thioridazine.

Sergio Sifontes-Rodríguez Niurka Mollineda-Diogo Lianet Monzote-Fidalgo Alma Reyna Escalona-Montaño José Antonio Escario María Magdalena Aguirre-García Alfredo Meneses-Marcel

Published in: Acta parasitologica (2023)

Thioridazine was effective against the promastigote and intracellular amastigote stages of three Leishmania species and in a mouse model of cutaneous leishmaniasis, supporting the potential repurposing of this drug as an antileishmanial agent.

Keyphrases

mouse model
human health
adverse drug
emergency department
genetic diversity
drug induced