Smoothened loss is a characteristic of neuroendocrine prostate cancer.

Lili WangHaiying LiZhang LiMing LiQi TangChunxiao WuZhiming Lu

Published in: The Prostate (2021)

These results demonstrate that SMO loss is a characteristic of NEPC and that detecting SMO by IHC could aid pathologists in NEPC diagnosis. SMO loss may promote NEPC pathogenesis by modulating AR signaling.

Keyphrases

prostate cancer
radical prostatectomy
signaling pathway