Histone deacetylase 1 and 3 inhibitors alleviate colon inflammation by inhibiting Th17 cell differentiation.

Zhengrong GuXiaotian ChenDandan ZhuSongting WuChenggong Yu

Published in: Journal of clinical laboratory analysis (2022)

HDAC1 and 3 inhibitors can modulate the differentiation of inflammatory Th17 cells, downregulate IL-17A levels, and exert anti-inflammatory effects in experimental colitis mice, indicating that HDAC1 and 3 may be potential therapeutic targets for patients with IBD.

Keyphrases

histone deacetylase
oxidative stress
induced apoptosis
cell cycle arrest
signaling pathway
high fat diet induced
type diabetes
cell death
human health
pi k akt
climate change