Unlocking the Secrets of Adipose Tissue: How an Obesity-Associated Secretome Promotes Osteoblast Dedifferentiation via TGF-β1 Signaling, Paving the Path to an Adipogenic Phenotype.

Yasmin Silva Forte Vany Nascimento-Silva Caio Andrade-SantosIsadora Ramos-AndradeGeorgia Correa Atella Luiz Guilherme Kraemer-AguiarPaulo Roberto Falcão LealMariana Renovato-Martins Thereza Christina Barja-Fidalgo

Published in: Cells (2024)

Our findings demonstrate that obese subcutaneous AT promotes the dedifferentiation of osteoblasts and increases the adipogenic profile in these cells.

Keyphrases

adipose tissue
insulin resistance
weight loss
metabolic syndrome
induced apoptosis
type diabetes
high fat diet
cell cycle arrest
transforming growth factor
high fat diet induced
weight gain
endoplasmic reticulum stress
cell death
obese patients
cell proliferation
physical activity
skeletal muscle
bone regeneration