The synergism of Clinacanthus nutans Lindau extracts with gemcitabine: downregulation of anti-apoptotic markers in squamous pancreatic ductal adenocarcinoma.

Ling-Wei HiiSwee-Hua Erin LimChee-Onn LeongSwee-Yee ChinNgai-Paing TanKok-Song LaiChun Wai Mai

Published in: BMC complementary and alternative medicine (2019)

These results provide strong evidence of C. nutans extracts being inefficacious as monotherapy for cancer. Hence, it should not be used as a total substitution for any chemotherapy agents. However, SN extracts may synergise with gemcitabine in the anti-tumor mechanism.

Keyphrases

locally advanced
cell death
papillary thyroid
cell proliferation
rectal cancer
high grade
signaling pathway
squamous cell carcinoma
squamous cell
radiation therapy
open label
clinical trial
childhood cancer
study protocol