Tissue or liquid rebiopsy? A prospective study for simultaneous tissue and liquid NGS after first-line EGFR inhibitor resistance in lung cancer.

Yen-Ting LinChao-Chi HoWei-Hsun HsuWei-Yu LiaoChing-Yao YangChong-Jen YuTzu-Hsiu TsaiJames Chih-Hsin YangShang-Gin WuChia-Lin HsuMin-Shu HsiehYen-Lin HuangChia-Ling WuJin-Yuan Shih

Published in: Cancer medicine (2023)

NGS after EGFR-TKI resistance may detect targetable drivers besides T790M. To do either liquid or tissue NGS only could miss patients with T790M. To do tissue and liquid NGS in parallel after EGFR-TKI resistance may find more patients with targetable cancers.

Keyphrases

tyrosine kinase
small cell lung cancer
epidermal growth factor receptor
ionic liquid