Population pharmacokinetics and pharmacodynamics of dobutamine in neonates on the first days of life.
Maarja HallikMari-Liis IlmojaJoseph F StandingHiie SoeorgTiiu JalasMaila RaidmäeKarin UiboKristel KöbasMargit SõnajalgKalev TakkisRūta VeigureKarin KipperJoel StarkopfTuuli MetsvahtPublished in: British journal of clinical pharmacology (2020)
In the postnatal transitional period, PK of dobutamine was described by a 1-compartmental linear model, CL related to BW and PMA. A concentration-response relationship with haemodynamic variables has been established.