Efficient tailoring of platinum nanoparticles supported on multiwalled carbon nanotubes for cancer therapy.
Mohamed R BerberHoda ElkhenanyInas H HafezAhmed El-BadawyMohamed EssawyNagwa El-BadriPublished in: Nanomedicine (London, England) (2020)
Aim: Therapeutically targeting cancer stem cells (CSCs), which play a role in tumor initiation and relapse, remains challenging. Materials & methods: Novel-formulated platinum nanoparticles (Pt-NPs) supported on polybenzimidazole (PBI)-functionalized polymers and multiwalled carbon nanotubes (MWCNT) were prepared and their effect on CSCs was evaluated. Results: Pt-NPs showed homogenous distribution on the surface of MWCNT/PBI composites, with very narrow particle size. MWCNT/PBI/Pt-NPs resulted in a dramatic decrease in the proliferation rate of CSCs but not bone marrow mesenchymal stem cells (BM-MSCs). Quantitative gene expression analysis revealed that MWCNT/PBI/Pt had a significant inhibitory effect on the epithelial-mesenchymal transition and cell cycle markers of CSCs. Conclusion: MWCNT/PBI/Pt exhibited a specific cytotoxic effect on breast CSCs but not on adult stem cells.
Keyphrases
- cancer stem cells
- carbon nanotubes
- cell cycle
- stem cells
- cancer therapy
- epithelial mesenchymal transition
- perovskite solar cells
- signaling pathway
- mesenchymal stem cells
- cell proliferation
- drug delivery
- high resolution
- genome wide identification
- quantum dots
- dna methylation
- gold nanoparticles
- bone marrow
- transcription factor
- reduced graphene oxide
- umbilical cord