Gene regulation of infection-associated L-tartrate metabolism in Salmonella enterica serovar Typhimurium.
Vivian K RojasMaria G WinterAngel G JimenezNatasha W TannerStacey L CrockettLuisella SpigaDavid R HendrixsonSebastian E WinterPublished in: bioRxiv : the preprint server for biology (2024)
integrates two infection-relevant cues, substrate availability and exogenous electron acceptors, to control L-tartrate metabolism. From our experiments, we propose a model for how L-tartrate metabolism is regulated in response to different metabolic cues in addition to characterizing two previously unknown transcriptional regulators. This study expands our understanding of how microbes combine metabolic cues to enhance fitness during infection.