Genomic complexity predicts resistance to endocrine therapy and CDK4/6 inhibition in hormone receptor-positive (HR+)/HER2-negative metastatic breast cancer.

Andrew A Davis Jingqin R Luo Tiantian Zheng Chao Dai Xiaoxi Dong Lu Tan Rama Suresh Foluso O Ademuyiwa Caron Rigden Timothy P Rearden Katherine K Clifton Katherine N Weilbaecher Ashley Frith Pavankumar K Tandra Tracy Summa Brittney Haas Shana Thomas Leonel F Hernandez-Aya Lindsay L Peterson Xiaohong Wang Shujun J Luo Kemin Zhou Pan Du Shidong Jia Bonnie L King Jairam Krishnamurthy Cynthia X Ma

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Genomic complexity detected by non-invasive profiling of bTMB and bCNB predicted poor outcomes in patients treated with ET and CDK4/6i and identified early disease progression before imaging. Novel treatment strategies including immunotherapy-based combinations should be investigated in this population.

Keyphrases

metastatic breast cancer
cell cycle
copy number
high resolution
single cell
atomic force microscopy
type diabetes
cell proliferation
skeletal muscle
bone marrow
cell therapy
adipose tissue
high speed
genome wide
single molecule
fluorescence imaging
weight loss