Late-onset MELAS syndrome in a 46-year-old man with initial symptom of chest tightness: a case report.
Ai WangJi ZhaoYun ZhaoYan YanPublished in: European heart journal. Case reports (2023)
The patient presented with chest tightness in adulthood, without any accompanying psychoneurological symptoms. However, the patient presented with other symptoms, including diabetes mellitus, hearing loss, abnormal lactate levels, ischaemic lesions on head MRI, and left ventricular hypertrophy. By identifying a mutation in the MT-TL1 gene and conducting a muscle biopsy, the diagnosis of MELAS syndrome was definitively confirmed.
Keyphrases
- late onset
- case report
- left ventricular
- early onset
- hearing loss
- magnetic resonance imaging
- heart failure
- skeletal muscle
- depressive symptoms
- contrast enhanced
- genome wide
- acute myocardial infarction
- hypertrophic cardiomyopathy
- physical activity
- coronary artery disease
- adipose tissue
- aortic stenosis
- fine needle aspiration
- left atrial
- glycemic control
- dna methylation
- percutaneous coronary intervention
- magnetic resonance
- cardiac resynchronization therapy
- early life
- genome wide identification