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Serum proteome profiles in patients treated with targeted temperature management after out-of-hospital cardiac arrest.

Gabriele LileikyteAnahita BakochiAshfaq AliMarion Moseby-KnappeTobias CronbergHans FribergGisela LiljaHelena LevinFilip ÅrmanSven KjellströmJosef DankiewiczChristian HassagerJohan MalmströmNiklas Nielsen
Published in: Intensive care medicine experimental (2023)
Serum proteome profiling revealed an increase in inflammatory/immune responses and apoptosis in patients with poor outcome. In patients with good outcome, an increase in proteolysis was observed, whereas TTM-level only had a modest effect on the proteome profiles. Further validation of the differentially abundant proteins in response to neurological outcome is necessary to validate novel biomarker candidates that may predict prognosis after cardiac arrest.
Keyphrases
  • cardiac arrest
  • immune response
  • oxidative stress
  • single cell
  • cardiopulmonary resuscitation
  • endoplasmic reticulum stress
  • cell death
  • signaling pathway
  • cerebral ischemia