Experimental Study of Hepatocellular Carcinoma Treatment by Shikonin Through Regulating PKM2.
Tong LiuSainan LiLiwei WuQiang YuJingjing LiJiao FengJie ZhangJiaojiao ChenYuting ZhouJie JiKan ChenYuqing MaoFan WangWeiqi DaiXiaoming FanJianye WuChuan-Yong GuoPublished in: Journal of hepatocellular carcinoma (2020)
By inhibiting PKM2, shikonin inhibited proliferation and glycolysis and induced cell apoptosis in HCC cells. The effect of shikonin on tumor cell proliferation, apoptosis and glycolsis will make it promising drug for HCC patients.
Keyphrases
- cell proliferation
- cell cycle arrest
- signaling pathway
- end stage renal disease
- induced apoptosis
- ejection fraction
- oxidative stress
- newly diagnosed
- chronic kidney disease
- endoplasmic reticulum stress
- pi k akt
- cell death
- cell cycle
- emergency department
- diabetic rats
- high glucose
- combination therapy
- electronic health record