ALOX5 contributes to glioma progression by promoting 5-HETE-mediated immunosuppressive M2 polarization and PD-L1 expression of glioma-associated microglia/macrophages.

Tao ChenJiangang LiuChenci WangZhengwei WangJiayi ZhouJiani LinJie MaoTingzheng PanJianwei WangHongchao XuXiaosheng HeDinglan WuZhuohao Liu

Published in: Journal for immunotherapy of cancer (2024)

Our findings reveal a pivotal role of the ALOX5/5-HETE axis in regulating GAMs and highlight the ALOX5-targeted nanobody as a potential therapeutic agent, which could potentiate immune checkpoint therapy for glioma.

Keyphrases

genome wide
single cell
neuropathic pain
gene expression
cancer therapy
dna methylation
spinal cord
drug delivery