Long-term dietary nitrate supplementation slows the progression of established atherosclerosis in ApoE -/- mice fed a high fat diet.

Yang LiuKevin D CroftTrevor A MoriTracey A GaspariBarbara K Kemp-HarperNatalie C Ward

Published in: European journal of nutrition (2023)

mice fed a HFD. This appears to be mediated in part through a XOR-dependent reduction of nitrate to NO, as well as enhanced eNOS activation via increased Akt and eNOS phosphorylation.

Keyphrases

high fat diet
insulin resistance
high fat diet induced
adipose tissue
nitric oxide
nitric oxide synthase
pi k akt
drinking water
endothelial cells
signaling pathway
cardiovascular disease
cell proliferation
metabolic syndrome
type diabetes
skeletal muscle
wild type
protein kinase