Heterogeneity of human prostate carcinoma-associated fibroblasts implicates a role for subpopulations in myeloid cell recruitment.
Renee E VickmanMeaghan M BromanNadia A LanmanOmar E FrancoPutu Ayu G SudyantiYang NiYuan JiBrian T HelfandJacqueline PetkewiczMichael C PaterakosSusan E CrawfordTimothy L RatliffSimon W HaywardPublished in: The Prostate (2019)
CAF clustering based on DE gene expression supports the concept that clusters have unique functions within the TME, including a role in immune/inflammatory cell recruitment. These data suggest that CCL2 produced by CAF may be involved in the recruitment of inflammatory cells, but may also directly regulate the growth of the tumor. Further studies aimed at characterizing the subpopulation(s) of CAF which promote immune cell recruitment to the TME and/or stimulate prostate cancer growth and progression will be pursued.
Keyphrases
- prostate cancer
- single cell
- gene expression
- rna seq
- induced apoptosis
- cell therapy
- oxidative stress
- endothelial cells
- radical prostatectomy
- dna methylation
- bone marrow
- acute myeloid leukemia
- stem cells
- dendritic cells
- cell cycle arrest
- liver injury
- big data
- benign prostatic hyperplasia
- endoplasmic reticulum stress
- drug induced