Polyfunctional, Proinflammatory, Tissue-Resident Memory Phenotype and Function of Synovial Interleukin-17A+CD8+ T Cells in Psoriatic Arthritis.

Kathryn J A SteelUshani SrenathanMichael RidleyLucy E DurhamShih-Ying WuSarah E RyanCatherine D HughesEstee ChanBruce W KirkhamLeonie S Taams

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

Our results identify synovial Tc17 cells as a polyclonal subset of Trm cells characterized by polyfunctional, proinflammatory mediator production and CXCR6 expression. The molecular signature and functional profiling of these cells may help explain how Tc17 cells can contribute to synovial inflammation and disease persistence in PsA and possibly other types of SpA.

Keyphrases

induced apoptosis
prostate cancer

endoplasmic reticulum stress
signaling pathway

cell proliferation
patient safety

single cell