Game theoretic centrality: a novel approach to prioritize disease candidate genes by combining biological networks with the Shapley value.

Min Woo SunStefano MorettiKelley M PaskovNate T StockhamMaya VarmaBrianna S ChrismanPeter Y WashingtonJae-Yoon JungDennis Paul Wall

Published in: BMC bioinformatics (2020)

Game theoretic centrality can prioritize influential, disease-associated genes within biological networks, and assist in the decoding of polygenic associations to complex disorders like autism.

Keyphrases

autism spectrum disorder
genome wide
virtual reality
intellectual disability
gene expression