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The Promising Therapeutic Potential of Oligonucleotides for Pulmonary Fibrotic Diseases.

Divyani PaulMadelyn H MillerJoshua R BornShayak SamaddarHuanzhen NiHugo AvilaVenkata R KrishnamurthyKannan Thirunavukkarasu
Published in: Expert opinion on drug discovery (2022)
ONTs provide a promising therapeutic approach for the treatment of fibrotic diseases of the lung, particularly because ONTs directly delivered to the lung show little systemic side effects compared to current therapeutic strategies. Dry powder aerosolized inhalers may be a good strategy for getting ONTs into the lung in humans. However, as of now, no dry powder ONTs have been approved for use in the clinical setting, and this challenge must be overcome for future therapies. Various delivery methods that can aid in direct targeting may also improve the use of ONTs for lung fibrotic diseases.
Keyphrases
  • systemic sclerosis
  • pulmonary hypertension
  • drug delivery
  • cancer therapy