Regulation of angiogenesis by signal sequence-derived peptides.

Mean Ghim Linyan WeiJae-Joon JungErlinda TheGunjan KukrejaAfarin NeishabouriAzmi A AhmadM Zawwad RazaArvene GolbaziKeshvad HedayatyanfardLei NieJiasheng ZhangMehran M Sadeghi

Published in: bioRxiv : the preprint server for biology (2024)

DCBLD2 SS along with its derivative peptides can promote VEGFR2 signaling and angiogenesis. Synthetic peptides based on DCBLD2 SS hold promise as therapeutic agents for regulating angiogenesis. Importantly these findings refine the traditional view of signal sequences as mere targeting elements, revealing a role in cellular signaling. This opens new avenues for research and therapeutic strategies.

Keyphrases

vascular endothelial growth factor
endothelial cells
amino acid
wound healing
machine learning
deep learning