CTLA4 prohibits T cells from cross-dressing.

Published in: The Journal of experimental medicine (2023)

In this issue of JEM, Xiaozheng Xu et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20221391) report that the inhibitory protein CTLA4 internalizes in cis the B7 stimulatory molecules previously "gnawed" by T cells from antigen-presenting cells (APCs) and in doing so prevents stimulatory T-T interactions.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
case report
binding protein
protein protein
amino acid
oxidative stress
wound healing