β-Cyclodextrin⁻Hyaluronic Acid Polymer Functionalized Magnetic Graphene Oxide Nanocomposites for Targeted Photo-Chemotherapy of Tumor Cells.
Wenting LiangYu HuangDongtao LuXuewen MaTao GongXiaodong CuiBaofeng YuCheng YangChuan DongShaomin ShuangPublished in: Polymers (2019)
A multifunctional targeted drug delivery platform (CDHA⁻MGO) has been successfully constructed by grafting β-cyclodextrin⁻hyaluronic acid polymers (CDHA) to Fe₃O₄⁻graphene oxide (MGO). The obtained CDHA⁻MGO nanocomposite has good water-dispersibility, easy magnetic separation, high near-infrared (NIR) photothermal heating, and excellent biocompatibility. The β-cyclodextrin-hyaluronic acid polymers efficaciously enhance the doxorubicin (DOX) loading amount up to 485.43 mg·g-1. Meanwhile, the Fe₃O₄⁻graphene oxide provides a facile photothermal response mechanism to handle the NIR-triggered release of DOX in weak acidic solvent environments. Significantly, the DOX-loaded nanocomposite (DOX@CDHA⁻MGO) has displayed CD44 receptor-mediated active targeting recognition and chemo-photothermal synergistic therapy of hepatoma cells. These findings suggest that the as-prepared drug delivery platform would be of valuable potential for cancer-targeted photo-chemotherapy.
Keyphrases
- hyaluronic acid
- cancer therapy
- drug delivery
- drug release
- reduced graphene oxide
- ionic liquid
- quantum dots
- molecularly imprinted
- photodynamic therapy
- visible light
- locally advanced
- solid phase extraction
- induced apoptosis
- carbon nanotubes
- capillary electrophoresis
- high throughput
- gold nanoparticles
- papillary thyroid
- highly efficient
- fluorescence imaging
- wastewater treatment
- stem cells
- squamous cell
- mesenchymal stem cells
- electron transfer
- lymph node metastasis
- bone marrow
- cell proliferation
- chemotherapy induced
- endoplasmic reticulum stress
- climate change
- high resolution
- simultaneous determination
- childhood cancer